1935 - 28-year-old Vincent Velcoro is sentenced to death, but is given a chance to remute his sentence by volunteering for S.H.A.D.E. experiments.
1937 - 30-year-old Vincent Velcoro's physiology is altered through experimentation. He becomes a vampire.
1939 - Frankenstein becomes the leader of the S.H.A.D.E. wartime assault team, the Creature Commandos, including J.A.K.E., 19-year-old Warren Griffith & 32-year-old Vincent Velcoro.
1942 - 35-year-old Vincent Velcoro earns his pardon, but stays in the fight with the Creature Commandos. J.A.K.E. suffers massive damage fighting a T-Rex on Dinosaur Island. He is rebuilt as J.A.K.E. 2, now with internal weapons.
40 years ago - Bones is born as the result of a failed mutogenic test by S.H.A.D.E. He is kidnapped by Doctor Love, the scientist in charge of the test, and raised as his experiment.
28 years ago - 27-year-old Lanford Terrill takes a permanent position with S.H.A.D.E. and retires from superheroics, not realizing that it has gone rogue.
25 years ago - 30-year-old Lanford Terrill's son Ray Terrill is born, and genetically manipulated in utero to enhance his metapowers. S.H.A.D.E. places him in a foster home for observation. Caitlin Fairchild is born & kidnapped to be genetically adapted. 19-year-old Cole Cash is secretly genetically manipulated while serving as a member of Team 7, enhancing his natural psionics.
18 years ago - Frankenstein is recovered by the DEO, who commission him to battle his old employers, S.H.A.D.E.
13 years ago - John Corben is nearly killed in a massive car accident. His body is recovered by S.H.A.D.E., who put his brain into a indestructible robotic body covered with cloned body tissue. He escapes and rampages, but it stopped by Superman.
11 years ago - 25-year-old Thomas Tresser's brother is killed. He discovers that he was killed by his own agency, and goes rogue to bring down S.H.A.D.E.
9 years ago - S.H.A.D.E. begins covertly drugging 16-year-old Caitlin Fairchild to activate her metagene.
8 years ago - 17-year-old Ray Terrill's foster father is killed in a car accident. He discovers his light manipulation powers, and the truth about his actual father, 47-year-old Lanford Terrill. He takes up the name the Ray, confronting S.H.A.D.E. When Lanford learns the truth about them, he turns on them, sacrificing his life to save his son.
7 years ago - 18-year-old Caitlin Fairchild's metagene activates. S.H.A.D.E. tries to kidnap her her, but she fights them off & helps Tomas Tresser bring them down.